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Updated: Mar 17, 2026

Isolation of Lung Retinoid-Containing Cells by Cell Sorting
Published on: April 11, 2025
Vitamin A-retinoid signaling in pulmonary development and disease
Hector A Marquez1, Wellington V Cardoso2
1Pulmonary Center, Boston University School of Medicine, Boston, MA, 02118, USA. hemarque@bu.edu.
Abstract:
Retinoic acid (RA), the active form of vitamin A, regulates key developmental processes in multiple organs. In the developing lung, RA is crucial for normal growth and differentiation of airways. Disruption in RA signaling or vitamin A deficiency (VAD) has been linked to aberrant development of the lung including alterations in the airway smooth muscle (SM) differentiation, development, and function. These alterations have been linked to disease states including asthma in both human and animal models.
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