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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
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Type III Hyperlipoproteinemia: Still Worth Considering?

Conrad B Blum1

  • 1Columbia University College of Physicians and Surgeons, New York, NY 10019, USA.

Progress in Cardiovascular Diseases
|August 3, 2016
PubMed
Summary

Familial type III hyperlipoproteinemia (HLP) is a genetic disorder impacting lipid metabolism. Understanding apolipoprotein E (apoE) variants is key to managing this condition through diet and medication.

Keywords:
Apolipoprotein EDysbetalipoproteinemiaRemnant lipoproteinsType III hyperlipoproteinemia

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Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Metabolic Disorders

Background:

  • Familial type III hyperlipoproteinemia (HLP) identified over 60 years ago.
  • HLP highlights the critical role of apolipoprotein E (apoE) in clearing remnant lipoproteins.
  • Reveals the significant atherogenicity of remnant lipoproteins.

Purpose of the Study:

  • Trace the historical understanding of type III HLP.
  • Discuss genetic variants of apoE contributing to type III HLP.
  • Describe treatment responses to lifestyle and pharmacotherapy.

Main Methods:

  • Literature review of familial type III hyperlipoproteinemia.
  • Analysis of apolipoprotein E genetic variants.
  • Evaluation of treatment outcomes for HLP.

Main Results:

  • Established the role of apoE in lipoprotein remnant clearance.
  • Identified genetic variations in apoE linked to HLP.
  • Demonstrated HLP's responsiveness to lifestyle changes and medication.

Conclusions:

  • Type III HLP is a genetically influenced lipid disorder.
  • ApoE genetics are central to HLP pathogenesis.
  • Lifestyle modifications, particularly diet, are effective in managing HLP.