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Updated: Mar 17, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
In vivo effect of copper status on cisplatin-induced nephrotoxicity
Ludmila V Puchkova1,2,3, Alexey N Skvortsov4, Paolo Rusconi5
1Laboratory of Trace Elements Metabolism, ITMO University, Kronverkskiy Pr. 49, St. Petersburg, Russia, 197101.
Abstract:
Cisplatin is a widely used antitumor agent; however, tumor resistance and severe side effects limit its use. It is well accepted that cisplatin toxicity can be modulated in vitro in cell cultures by copper salts. In the present work, mice with different blood serum copper status were treated with a single intraperitoneal cisplatin injection at a dose of 5 mg/kg, monitored for 3 days in metabolic cages and analyzed for renal function. Both copper-deficient and copper-overloaded mice displayed more severe early proteinuria and retarded platinum excretion than control mice. The effects of copper status on cisplatin-induced nephrotoxicity are discussed.
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