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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and

Catharina C Gross¹, Andreas Schulte-Mecklenbeck¹, Uta Hanning²

¹Department of Neurology, University Hospital Münster, Münster, Germany.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|August 3, 2016

Abstract

Background:

Distinct lesion topography in relapsing-remitting multiple sclerosis (RRMS) might be due to different antigen presentation and/or trafficking routes of immune cells into the central nervous system (CNS).

Objective:

To investigate whether distinct lesion patterns in multiple sclerosis (MS) might be associated with a predominance of distinct circulating T-helper cell subset as well as their innate counterparts.

Methods:

Flow cytometric analysis of lymphocytes derived from the peripheral blood of patients with exclusively cerebral (n = 20) or predominantly spinal (n = 12) disease manifestation.

Results:

Patients with exclusively cerebral or preferential spinal lesion manifestation were associated with increased proportions of circulating granulocyte-macrophage colony-stimulating factor (GM-CSF) producing T_H1 cells or interleukin (IL)-17-producing T_H17 cells, respectively. In contrast, proportions of peripheral IL-17/IL-22-producing lymphoid tissue inducer (LTi), the innate counterpart of T_H17 cells, were enhanced in RRMS patients with exclusively cerebral lesion topography.

Conclusions:

Distinct T-helper and T-helper-like innate lymphoid cell (ILC) subsets are associated with different lesion topography in RRMS.

Keywords:

Multiple sclerosis TH1 TH17 innate lymphoid cell lesion distribution lymphoid tissue inducer

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Keywords:

Multiple sclerosis TH1 TH17 innate lymphoid cell lesion distribution lymphoid tissue inducer

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