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Human excimer laser lamellar keratectomy. A clinical study
D M Taylor1, F A L'Esperance, R A Del Pero
1Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington.
Ophthalmology
|May 1, 1989
Summary
Excimer laser lamellar keratectomy (ArFl 193 nm) successfully reshaped corneas in blind human eyes, showing minimal haze and good visual potential. Post-procedure healing involved epithelial thickening and stromal remodeling with keratocyte activation.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Laser Technology
Background:
- Blindness due to corneal irregularities presents a significant challenge.
- Excimer laser technology offers precise tissue ablation for refractive correction.
Purpose of the Study:
- To evaluate the safety and efficacy of excimer laser lamellar keratectomy for corneal reshaping in blind human eyes.
- To assess the histopathologic changes and visual outcomes following the procedure.
Main Methods:
- Ten blind human eyes underwent excimer laser (ArFl 193 nm) lamellar keratectomy.
- Follow-up included slit-lamp examination, pachymetry, keratometry, refraction, and digital keratoscopy.
- Histopathologic analysis via transmission electron microscopy was performed on enucleated eyes.
Main Results:
- Eyes remained grossly clear post-ablation with mild superficial haze observed.
- Corneal reshaping showed progressive stromal filling but a partial loss of initial diopteric correction.
- Histopathology revealed minimal tissue damage, no inflammation, epithelial thickening, and keratocyte activation with increased protein synthesis.
Conclusions:
- Excimer laser lamellar keratectomy is a viable option for corneal reshaping in blind eyes.
- The procedure demonstrates a favorable safety profile with manageable stromal healing and epithelial response.