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Mitochondria-targeting ratiometric fluorescent probe for γ-glutamyltranspeptidase and its application to colon cancer
Seokan Park1, Dong Jun Bae2, Yeon-Mi Ryu2
1Department of Chemistry, Hankuk University of Foreign Studies, Yongin 449-791, Korea. haejkim@hufs.ac.kr.
Abstract:
A mitochondria-targeting ratiometric probe was designed for γ-glutamyltranspeptidase (γGT). Mechanistic study by HPLC and an inhibitor assay showed that the probe underwent γGT-mediated amide-to-amine transformation and induced a ratiometric fluorescence response in cellular mitochondria. Further application was successful for the detection of cancerous colons in mice.
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