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Related Experiment Video

Updated: Mar 17, 2026

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
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Heavy Metal-Induced Systemic Dysfunction Attenuated by Tannic Acid.

Mohammad Ashafaq1, Pooja Sharma1, Saima Khatoon1

  • 1Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, India.

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
|August 3, 2016
PubMed
Summary
This summary is machine-generated.

Tannic acid (TA) administration protected rats from lead acetate-induced oxidative stress in the liver and kidney. TA treatment significantly reduced oxidative damage and restored antioxidant levels, highlighting its protective potential against lead intoxication.

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Area of Science:

  • Toxicology
  • Biochemistry
  • Cell Biology

Background:

  • Lead toxicity poses a significant public health risk.
  • Lead acetate (LA) exposure induces oxidative stress in vital organs.
  • Understanding protective agents against lead poisoning is crucial.

Purpose of the Study:

  • To investigate the protective effects of tannic acid (TA) against lead acetate (LA)-induced oxidative stress.
  • To evaluate TA's impact on antioxidant levels and histological damage in rat liver and kidney.
  • To determine if TA's antioxidative properties mitigate lead intoxication.

Main Methods:

  • Rats were administered oral tannic acid (TA) at 50 mg/kg, 3 times/week for 2 weeks.
  • Lead acetate (LA) was administered intraperitoneally at 50 mg/kg, 3 times/week for 2 weeks.
  • Oxidative stress markers, antioxidant enzyme activity, and histopathological changes in liver and kidney were assessed.

Main Results:

  • LA treatment significantly increased oxidative stress markers and caused histological damage in rat liver and kidney.
  • LA exposure led to a significant depletion of nonenzymatic and enzymatic antioxidants.
  • TA treatment significantly attenuated these LA-induced alterations, reducing oxidative stress biomarkers and protecting tissues.

Conclusions:

  • Tannic acid (TA) exhibits potent antioxidant properties.
  • TA effectively protected rat liver and kidney against lead acetate-induced oxidative damage.
  • TA consumption may offer a protective strategy against lead intoxication due to its antioxidative effects.