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Promazine, a phenothiazine derivative, effectively activates sleep for electroencephalogram (EEG) recordings in children, including infants. This method is beneficial for various epilepsies with minimal EEG alteration compared to other sedatives.
Area of Science:
- Neuroscience
- Clinical Neurology
- Pediatric Medicine
Abstract:
The authors report on the sleep activation of the EEG-recordings by Promazine a Phenothiazine derivative that can be used also in babies and in those elder children who does not tolerate sleep deprivation. The EEG-s are much less altered then by other related compounds or by Barbiturates. The greatest efficacy could be reached in generalized epilepsies, but the method was helpful in other epilepsy forms too. It is emphasized that in no case of acute neurological symptoms of not epileptic origin showed the Promazine induced sleep a convulsive activity.