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miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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Dissecting major signaling pathways in prostate cancer development and progression: Mechanisms and novel therapeutic

Senthilmurugan Ramalingam1, Vidya P Ramamurthy1, Vincent C O Njar2

  • 1Department of Pharmacology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201-1559, USA.

The Journal of Steroid Biochemistry and Molecular Biology
|August 3, 2016
PubMed

Insights

Prostate cancer (PCa) is a common male cancer. While androgen deprivation therapy (ADT) works initially, most cancers become resistant, leading to aggressive castration-resistant prostate cancer (CRPC) with no effective treatments.

Area of Science:

  • Oncology
  • Urology
  • Cancer Biology

Background:

  • Prostate cancer (PCa) is a leading cause of cancer mortality in men.
  • Early-stage PCa relies on androgens, making androgen deprivation therapy (ADT) effective initially.
  • Most patients develop resistance to ADT, progressing to aggressive castration-resistant prostate cancer (CRPC).

Purpose of the Study:

  • To review major signaling pathways in prostate cancer development and castration resistance.
  • To discuss therapeutic strategies targeting key signaling mechanisms in CRPC.

Main Methods:

  • Literature review of signaling pathways in prostate cancer.
  • Analysis of therapeutic strategies for castration-resistant prostate cancer.

Main Results:

  • Identified key signaling pathways driving PCa growth and castration resistance.
  • Highlighted current and emerging therapeutic targets for CRPC.

Conclusions:

  • Understanding signaling pathways is crucial for combating PCa and CRPC.
  • Targeted therapies offer potential for improved CRPC treatment outcomes.
Keywords:
AndrogenCastration resistant prostate cancerProstate cancerSignaling pathways

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