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Prehypertension and Left Ventricular Diastolic Dysfunction in Middle-Aged Koreans

Shin Yi Jang1, Sujin Kim1, Chang Kwan Lee2

  • 1Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Korean Circulation Journal
|August 3, 2016
PubMed

Insights

Prehypertension (preHT) is linked to left ventricular diastolic dysfunction, a sign of heart muscle damage, particularly in middle-aged Korean men. This finding highlights the importance of monitoring blood pressure for cardiovascular health.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Diagnostic Imaging

Background:

  • Left ventricular diastolic dysfunction indicates myocardial damage, often linked to hypertension.
  • The relationship between diastolic dysfunction severity and blood pressure categories requires further investigation.
  • Prehypertension (preHT) is a significant public health concern.

Purpose of the Study:

  • To examine the association between left ventricular diastolic dysfunction and prehypertension in apparently healthy adults.
  • To determine if prehypertension is an independent risk factor for diastolic dysfunction.
  • To explore potential gender-specific differences in this association.

Main Methods:

  • A cohort of 4261 Koreans aged 45-64 years without prior cardiovascular disease underwent routine health examinations.
  • Echocardiography was used to assess left ventricular diastolic dysfunction.
  • Participants were categorized into normotensive, prehypertensive, and hypertensive groups based on resting blood pressure.

Main Results:

  • The prevalence of prehypertension was 42.1% in the study population.
  • Left ventricular diastolic dysfunction (grades 1 and 2) was significantly more common in individuals with preHT, even after adjusting for multiple risk factors (OR 1.66 for grade 1).
  • This association was particularly pronounced in middle-aged Korean males.

Conclusions:

  • Left ventricular diastolic dysfunction is significantly associated with prehypertension in middle-aged Korean males.
  • Early detection and management of prehypertension may be crucial for preventing cardiac damage.
  • Further research is warranted to elucidate the mechanisms underlying this association.
Abstract

Keywords:
EchocardiographyMiddle-agedPrehypertensionVentricular dysfunction, left

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