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Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
Published on: October 6, 2022
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Novel immunological strategies for HIV-1 eradication
1Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Journal of Virus Eradication
|August 3, 2016
Summary
Despite advances in antiretroviral therapy (ART), HIV-1 persists in cellular reservoirs. This review explores early HIV-1 latency establishment and strategies to disrupt it for viral eradication.
Area of Science:
- Virology
- Immunology
- Infectious Diseases
Background:
- Antiretroviral therapy (ART) controls HIV-1 replication but does not eliminate the virus.
- Latent HIV-1 reservoirs are established early after infection, evading immune detection.
- These reservoirs persist long-term, posing a challenge for complete viral eradication.
Purpose of the Study:
- To review the early establishment of HIV-1 latency.
- To discuss current strategies for disrupting latent HIV-1 reservoirs.
- To explore novel approaches for HIV-1 eradication.
Main Methods:
- Review of preclinical studies on HIV-1 latency.
- Analysis of pharmacological induction strategies.
- Discussion of immune-enhancing interventions.
Main Results:
- Latent HIV-1 reservoirs form rapidly, often before detection in peripheral blood.
- Latently infected cells remain hidden from the immune system and can reactivate.
- Combined approaches of latency induction and immune enhancement show promise.
Conclusions:
- Understanding early HIV-1 latency is crucial for developing effective eradication strategies.
- Targeting latent reservoirs requires innovative therapeutic approaches.
- Future research focuses on combining latency-reversing agents with immune-based therapies for HIV-1 cure.
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