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Aminophylline Dosage In Asthma Exacerbations in Children: A Systematic Review

Lewis Cooney1, Ian Sinha2, Daniel Hawcutt1,2

  • 1Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, Merseyside, United Kingdom.

Plos One
|August 3, 2016
PubMed

Insights

Current intravenous aminophylline dosage for pediatric asthma exacerbations may not be optimal. Research indicates a weak link between dosage and symptom improvement, highlighting a need for better evidence to guide treatment.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Pharmacology
  • Evidence-Based Medicine

Background:

  • Asthma exacerbations in children require effective treatment with intravenous aminophylline.
  • Current dosage recommendations may be suboptimal, as serum concentrations do not reliably predict clinical improvement.

Purpose of the Study:

  • To evaluate the optimal dosage strategy for intravenous aminophylline in pediatric asthma exacerbations.

Main Methods:

  • A systematic review of 14 randomized controlled trials (RCTs) was conducted.
  • Searches were performed in CENTRAL, CINAHL, MEDLINE, and Web of Science databases in March 2016.
  • Included studies used intravenous aminophylline in children with acute asthma exacerbations and reported dosage and clinical outcomes.

Main Results:

  • A poor correlation was observed between administered aminophylline dosage and symptom resolution, length of hospital stay, or need for mechanical ventilation.
  • The evidence base for this review was limited by its reliance on indirect evidence.

Conclusions:

  • Current intravenous aminophylline dosage regimens may not ensure optimal safety and efficacy in children with asthma exacerbations.
  • Further research is needed to establish a clear correlation between dosage and patient-centered clinical outcomes to refine prescribing practices.
Abstract

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