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Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
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Infection01:20

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Intracellular Movement of Viruses and Bacteria01:10

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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Related Experiment Video

Updated: Mar 16, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
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Measles Virus Host Invasion and Pathogenesis.

Brigitta M Laksono1, Rory D de Vries2, Stephen McQuaid3

  • 1Department of Viroscience, Erasmus MC, 3015CN Rotterdam, The Netherlands. b.laksono@erasmusmc.nl.

Viruses
|August 3, 2016
PubMed
Summary

Measles virus causes a systemic disease with rash and fever, leading to temporary immune suppression. This review explores measles virus host invasion and pathogenesis, including its cellular receptors.

Keywords:
immune suppressionmeasles viruspathogenesistransmissiontropism

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Area of Science:

  • Virology
  • Immunology
  • Pathogenesis

Background:

  • Measles virus is a highly contagious negative-strand RNA virus transmitted via respiratory droplets.
  • Measles infection is characterized by fever, rash, cough, coryza, conjunctivitis, and transient immune suppression.
  • Despite immune suppression, measles induces a robust, lifelong virus-specific immune response.

Purpose of the Study:

  • To review current topics in measles virus host invasion and pathogenesis.
  • To highlight the identification of cellular receptors and their role in viral tropism.
  • To discuss the systemic nature and immune-modulating effects of measles virus infection.

Main Methods:

  • Review of existing literature on measles virus.
  • Discussion of in vivo studies in non-human primates.
  • Analysis of cellular receptor identification and function.

Main Results:

  • Measles virus initially infects CD150+ lymphocytes and dendritic cells.
  • Subsequent viral transmission occurs to nectin-4 expressing epithelial cells.
  • The virus exhibits systemic spread, respiratory transmission, and prolonged immune suppression.

Conclusions:

  • CD150 and nectin-4 are key cellular receptors for measles virus, influencing tropism and pathogenesis.
  • Measles virus possesses remarkable abilities for systemic infection, transmission, and immune evasion.
  • Understanding measles virus host invasion and pathogenesis is crucial for disease control.