EVALUATION OF ANTIOXIDANT ACTIVITY OF SOME IMINES DERIVATIVES OF L-ARGININE

Area of Science:

• Biochemistry
• Medicinal Chemistry

Background:

• L-Arginine, an alpha-amino acid, is involved in various physiological processes and diseases, including Alzheimer's, inflammation, and tissue regeneration.
• L-Arginine also possesses potential anti-atherosclerotic properties.
• Antioxidants play crucial roles in mitigating disease processes.

Purpose of the Study:

• To evaluate the antioxidant potential of novel imine derivatives synthesized from L-arginine.
• To compare the antioxidant activity of these derivatives against L-arginine.

Main Methods:

• The antioxidant capacity was assessed using in vitro assays: Phosphomolybdenum-reducing antioxidant power (PRAP) and Ferric reducing antioxidant power (FRAP).
• Standard assay protocols were employed with minor modifications.

Main Results:

• Most synthesized imine derivatives demonstrated superior antioxidant activity compared to L-arginine in both PRAP and FRAP assays.
• The most potent derivatives were formed by condensing L-arginine with 2,3-dihydroxybenzaldehyde (compound 2k) and 2-nitrobenzaldehyde (compound 2g).

Conclusions:

• Imine derivatives of L-arginine exhibit significant in vitro antioxidant potential.
• Aromatic substitution with nitro and hydroxyl groups on the imine derivatives enhances their antioxidant activity, making them more effective than L-arginine.