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Updated: Mar 16, 2026

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
Published on: March 11, 2022
Cerebral circulation in aging
Ken Nagata1, Takashi Yamazaki1, Daiki Takano1
1Department of Neurology, Clinical Research Institute, Yokohama General Hospital, Yokohama, Japan.
Abstract:
Cerebral circulation is known to be protected by the regulatory function against the hypoperfusion that will affect the cognitive function as a result of brain ischemia and energy failure. The regulatory function includes cerebrovascular autoregulation, chemical control, metabolic control, and neurogenic control, and those compensatory mechanisms can be influenced by hypertension, atherosclerosis, cardiac diseases, cerebrovascular diseases and aging. On the other hand, large and/or small infarction, intracranial hemorrhage, subarachnoid hemorrhage, atherosclerosis, amylod angiopathy are also more directly associated with cognitive decline not only in those with vascular cognitive impairment or vascular dementia but also those with Alzheimer's disease.
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