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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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REM sleep behavior disorder was associated with Parkinson's disease: a community-based study
Jian-Fang Ma1, Miao-Miao Hou1, Hui-Dong Tang1
1Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
BMC Neurology
|August 4, 2016
Summary
A modified REM sleep behavior disorder (RBD) questionnaire (RBD1Q-C) is a useful screening tool. Probable RBD (pRBD) is prevalent in rural China and linked to increased Parkinson's disease risk.
Area of Science:
- Neurology
- Sleep Medicine
- Epidemiology
Background:
- REM sleep behavior disorder (RBD) is a neurological condition.
- A validated screening tool is needed to assess probable RBD (pRBD) prevalence and its association with Parkinson's disease (PD).
Purpose of the Study:
- To validate the modified REM sleep behavior disorder single question (RBD1Q-C).
- To determine the prevalence of pRBD in a Chinese rural community using RBD1Q-C.
- To investigate the association between pRBD and PD.
Main Methods:
- Validation of RBD1Q-C involved 32 Chinese participants (14 idiopathic RBD patients, 18 controls) undergoing polysomnography (PSG).
- A door-to-door survey of 19,614 residents in Shanghai's Malu community assessed pRBD prevalence via RBD1Q-C and its link to PD.
Main Results:
- RBD1Q-C showed high sensitivity (100%) and good agreement with PSG (k=0.552).
- The prevalence of pRBD in the Malu community was 4.9%.
- In individuals over 50, pRBD was significantly associated with a 2.61-fold increased risk of PD.
Conclusions:
- RBD1Q-C is an effective screening tool for pRBD.
- pRBD is common in the Chinese rural population and linked to PD.
- Increased awareness and attention to pRBD are needed by patients, caregivers, and physicians.
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