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Transitory L-carnitine depletion in rat skeletal muscle by D-carnitine
O Arancio1, G Bonadonna, M Calvani
1Istituto di Neurologia, Universitá di Verona, Policlinico Borgo Roma.
Pharmacological Research
|March 1, 1989
Abstract:
Weanling and adult rats were intraperitoneally injected with D-carnitine for 40 days. After 15 days of treatment a statistically significant depletion in the muscle levels of free and total L-carnitine was observed, but after 40 days this depletion became slight and statistically not significant. These findings suggest the presence of a compensatory mechanism acting on the inhibition of L-carnitine transport into skeletal muscle fibres.