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Liver function declines with increased age.

Kasia P Cieslak1, Onno Baur1, Joanne Verheij2

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Liver function declines with increasing age, impacting surgical risk assessment. This study quantifies age-related liver function changes using quantitative liver function tests.

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Area of Science:

  • Hepatology
  • Geriatric Medicine
  • Surgical Oncology

Background:

  • Aging is not a contraindication for major surgery, but age-related liver changes are not well understood.
  • Liver function is critical for assessing surgical risk, especially in major liver resections.

Purpose of the Study:

  • To evaluate age-dependent changes in liver function.
  • To assess the relationship between patient age and quantitative liver function measurements.

Main Methods:

  • Utilized (99m)Tc-mebrofenin hepatobiliary scintigraphy (HBS) in 508 patients (203 healthy, 57 with HCC Child-Pugh A).
  • Calculated the age-corrected liver uptake rate (cMUR) for all participants.
  • Performed linear regression analysis to correlate age with cMUR.

Main Results:

  • A negative linear correlation was observed between age and cMUR in healthy individuals (r=0.244, p=0.000).
  • In patients with HCC (Child-Pugh A), no significant correlation was found, but a trend of declining liver function with age was noted.

Conclusions:

  • Liver function deteriorates with advancing age.
  • Age-related decline in liver function and regenerative capacity should be considered when evaluating surgical risk for major liver resections.