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Maria Giovanna Danieli1, Federica Pulvirenti2, Valeria Rocchi3

  • 1Clinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche & Ospedali Riuniti, Ancona, Italy.

Immunotherapy
|August 4, 2016
PubMed

Hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIg) is a new immunoglobulin product for replacement therapy in patients with primary antibody deficiencies (PAD). The pre-administration of recombinant human hyaluronidase associated with 10% immunoglobulin allowed the infusion of larger (up to 600 ml) amounts of immunoglobulin at a single infusion site, enabling patients to receive the necessary treatment in a single monthly dose. Here, we report the effectiveness and the tolerability of fSCIg in patients with severe PAD-related comorbidities: refractory autoimmune thrombocytopenia; systemic granulomatous disease; severe enteropathy, and Type I diabetes. We conclude that fSCIg could be a feasible option to improve the adherence to replacement therapy also by patients with severe PAD.

Keywords:
X-linked agammaglobulinemiacommon variable immunodeficiencycytopeniasenteropathyfacilitated subcutaneous immunoglobulingranulomatous diseaseimmunomodulation, intravenous immunoglobulinsubcutaneous immunoglobulinthrombocytopenia

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