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Whole Mount Labeling of Cilia in the Main Olfactory System of Mice
Published on: December 27, 2014
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Olfactory Dysfunction in IgG4-Related Disease.
Sayaka Yagi-Nakanishi1, Satoru Kondo1, Misako Kaneda1
1Division of Otorhinolaryngology, Head and Neck Surgery, Kanazawa University Graduate School of Medical Sciences , 13-1, Takara-machi, Kanazawa, Ishikawa 920-8641 , Japan and.
Chemical Senses
|August 4, 2016
Summary
IgG4-related disease often causes olfactory dysfunction, affecting over half of patients. This smell impairment is reversible, highlighting a new aspect of this systemic condition.
Area of Science:
- Otolaryngology
- Immunology
- Systemic Diseases
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a newly identified systemic condition.
- Sinonasal manifestations of IgG4-RD are not well understood.
- Olfactory function in IgG4-RD patients requires further investigation.
Purpose of the Study:
- To evaluate olfactory function in patients diagnosed with IgG4-related disease.
- To identify potential etiological factors for olfactory dysfunction in IgG4-RD.
- To determine the reversibility of olfactory impairment in IgG4-RD.
Main Methods:
- Twenty-five IgG4-RD patients underwent T&T olfactometry for olfactory assessment.
- Clinical data, including serum IgG4/IgE levels and CT scores, were analyzed.
- Inferior turbinate biopsies were performed in a subset of patients to correlate IgG4-positive cells with olfaction.
Main Results:
- 52% of IgG4-RD patients exhibited moderate to severe olfactory dysfunction.
- No significant differences in clinical features were observed between patients with and without olfactory dysfunction.
- No correlation was found between olfaction scores and the number of IgG4-positive cells in turbinate biopsies.
- Six patients with hyposmia (reduced smell) recovered normal olfactory function, with five responding to corticosteroids.
Conclusions:
- Olfactory dysfunction is a prevalent and potentially reversible manifestation of IgG4-related disease.
- This finding suggests olfactory impairment is a novel, significant feature of IgG4-RD.
- Further research is warranted to understand the mechanisms and management of olfactory dysfunction in IgG4-RD.
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