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Updated: Mar 16, 2026
An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Enterovirus D68 and Human Respiratory Infections
1MOH Key Laboratory of Systems Biology of Pathogens, and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, P.R. China.
Enterovirus D68 (EV-D68) causes respiratory illness, with recent global increases in severe cases. Current strains differ from the original, and no specific treatments exist.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Enterovirus D68 (EV-D68) is a significant respiratory pathogen.
- Rarely reported previously, EV-D68 has seen a notable increase in global respiratory disease cases.
- A 2014 US outbreak involved over 1,000 severe respiratory illness cases.
Purpose of the Study:
- To provide a comprehensive review of Enterovirus D68.
- To detail current knowledge on EV-D68 virology, epidemiology, clinical aspects, pathogenesis, and diagnostics.
Main Methods:
- Phylogenetic analysis of EV-D68 sequences.
- Review of existing literature on EV-D68.
Main Results:
- EV-D68 strains are classified into two lineages.
- Circulating EV-D68 strains possess genomic deletions absent in the prototype strain.
- Infections range from mild to severe, requiring intensive care.
Conclusions:
- EV-D68 poses a significant public health challenge due to increasing prevalence and severity.
- There are currently no specific vaccines or antiviral treatments for EV-D68 infections.
- Further research into EV-D68 pathogenesis and diagnostics is crucial.
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