[Preparation of rat fibrinogen]

For the first time, the fibrinogen preparation according to Blombäck was used to purify rat fibrinogen. Intermediate as well as final products were compared with those of human fibrinogen. Yields of final products were about 25% of plasma fibrinogen. Thrombin clottability amounted to 96.5 +/- 1.3% for rat fibrinogen and 95.0 +/- 1.1% for human fibrinogen, respectively. The integrity and the characteristic differences in molecular mass of rat and human fibrinogen chains were demonstrated by means of SDS-PAGE.