Synthesis of pyridylthiazoles as antisecretory agents

4-(3-Pyridyl)thiazole and 2-methylimidazo[1,2-a]pyridine derivatives with anticholinergic antisecretory activity were synthesized. Most of the compounds (3-16) were formed from carbohydrazide 2 and carbonitrile 9. Some thiazole derivatives, most of them containing nitrogen attached to the thiazole C-2 (19-20), were prepared from 17 and 18 by known method. Compounds 12 and 19b exerted a significant antisecretory whereas 5b, 12 and 19b an antiulcer activity.