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Isolation of Physiologically Active Thylakoids and Their Use in Energy-Dependent Protein Transport Assays
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Cotranslational signal-independent SRP preloading during membrane targeting

Justin W Chartron, Katherine C L Hunt, Judith Frydman

    Nature
    |August 4, 2016
    PubMed
    Summary

    Signal recognition particle (SRP) binds secretory proteins before their targeting signals are fully translated, aided by mRNA elements. This mechanism ensures accurate cotranslational membrane targeting, even with limited polypeptide information.

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