Reversal of Tetracycline Resistance in Escherichia coli by Noncytotoxic bis(Tryptophan)s
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Updated: Mar 16, 2026

Inducing a Site Specific Replication Blockage in E. coli Using a Fluorescent Repressor Operator System
Published on: August 21, 2016
Joseph W Meisel1, Mohit B Patel1, Evan Garrad1
1Center for Nanoscience, Departments of ‡Chemistry & Biochemistry and §Biology, University of Missouri - St. Louis , 1 University Blvd., St. Louis, Missouri 63121, United States.
Abstract:
Nine bis(tryptophan) derivatives (BTs) and two control compounds were synthesized and tested for antimicrobial activity against two Escherichia coli strains and a Staphylococcus aureus strain. The effects of linker type, shape, and conformational rigidity were manifested in dramatic differences in altering tetracycline potency when coadministered with that antibiotic. A reversal of resistance was observed for an E. coli strain having a TetA efflux pump. Survival of mammalian cells was assayed with good result.
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