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Related Experiment Video

Updated: Mar 16, 2026

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Secretory function of adipose tissue.

J Kuryszko, P Sławuta, G Sapikowski

Polish Journal of Veterinary Sciences

|August 4, 2016

Summary

Adipose tissue, particularly white adipose tissue, functions as an endocrine gland secreting adipokines that regulate metabolism. Dysfunction, or adiposopathy, contributes to insulin resistance and Type 2 diabetes, impacting animal health.

Area of Science:

Endocrinology
Metabolic Science
Veterinary Medicine

Background:

Mammals possess white adipose tissue (WAT) for energy storage and brown adipose tissue (BAT) for thermogenesis.
WAT functions as an endocrine gland, producing adipokines like leptin, adiponectin, resistin, apelin, and visfatin, which influence glucose and lipid metabolism.
Adipokines play critical roles in energy homeostasis, with some promoting insulin sensitivity and others inducing insulin resistance.

Purpose of the Study:

To explore the endocrine functions of adipose tissue and its role in metabolic regulation.
To understand the contribution of various adipokines to systemic metabolic health and disease.
To highlight the concept of adiposopathy and its implications for conditions like insulin resistance and Type 2 diabetes.

Main Methods:

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Review of existing literature on adipose tissue biology and adipokine function.
Analysis of the roles of specific adipokines (leptin, adiponectin, resistin, visfatin, apelin, TNF, IL-6) in metabolic processes.
Examination of the definition and consequences of adiposopathy.

Main Results:

WAT secretes adipokines that significantly impact glucose and lipid metabolism, energy balance, and inflammation.
Adipokines exhibit diverse functions: adiponectin and visfatin are generally beneficial, while resistin, TNF, and IL-6 can promote insulin resistance.
Adiposopathy, characterized by adipose tissue dysfunction, insulin/leptin resistance, and inflammation, is linked to obesity and Type 2 diabetes.

Conclusions:

Adipose tissue is a complex endocrine organ with a significant role in metabolic health.
Adipokine dysregulation and adiposopathy contribute to the development of metabolic diseases, including insulin resistance and Type 2 diabetes.
Understanding the endocrine role of adipose tissue is crucial for managing metabolic disorders in both humans and animals, particularly in veterinary medicine.