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[Cytokine profile in young children with acute stenotic laryngotracheitis]

Ольга І Гладченко1, Павло В Токарєв2, Олександр Б Надрага2

  • 1ЛЬВІВСЬКИЙ НАЦІОНАЛЬНИЙ МЕДИЧНИЙ УНІВЕРСИТЕТ ІМЕНІ ДАНИЛА ГАЛИЦЬКОГО, вул. Героїв Майдану 14 кв.4 м. Львів, Україна, Tel: +380967775377 hladchenko.olya@gmail.com.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|August 4, 2016
PubMed

Insights

Cytokine imbalances are key in croup pathogenesis for children. Recurrent croup shows a different cytokine correlation compared to initial cases, suggesting distinct inflammatory responses.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Respiratory Medicine

Background:

  • Acute stenotic laryngotracheitis (croup) is a severe complication of respiratory infections in children.
  • The precise role of cytokine levels in croup symptoms, severity, and outcomes remains unclear.

Purpose of the Study:

  • To investigate the cytokine profiles in young children diagnosed with acute stenotic laryngotracheitis (croup).

Main Methods:

  • Observed 112 children (12-36 months) with croup.
  • Analyzed serum cytokine levels (IL-1, IL-4, IL-6, IL-10, IL-17) and respiratory viruses.
  • Assessed croup severity using the Chan scale.

Main Results:

  • An imbalance between pro-inflammatory (IL-1, IL-6) and anti-inflammatory (IL-4, IL-10, IL-17) cytokines was observed in croup pathogenesis.
  • Children with croup exhibited significantly higher cytokine levels than those with acute laryngitis.
  • Recurrent croup cases lacked a significant correlation between inflammatory and anti-inflammatory cytokine concentrations.

Conclusions:

  • Elevated cytokine levels are characteristic of croup in children compared to acute laryngitis.
  • An imbalance in cytokine profiles is implicated in the pathogenesis of recurrent croup.
Abstract

Keywords:
acute stenotic laryngotracheitischildrencroupcytokines

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