Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of proximity to females on integument damage caused by self-enurination in male goats.

Research in veterinary science·2021

Same author

Differential effects of androgens, estrogens and socio-sexual context on sexual behaviors in the castrated male goat.

Hormones and behavior·2019

Same author

From Death to Health in 30 Days: A Hemochromatosis Case Report.

Dimensions of critical care nursing : DCCN·2018

Same author

The disease with hope: hairy cell leukemia.

Clinical journal of oncology nursing·2007

Same journal

Section: Book and Media.

Dimensions of critical care nursing : DCCN·2026

Same journal

Exploring RN Resignation Experiences.

Dimensions of critical care nursing : DCCN·2026

Same journal

Nursing Perspectives on Glycemic Control for Critically Ill Adults in the Intensive Care Unit: A Narrative Review.

Dimensions of critical care nursing : DCCN·2026

Same journal

Quantitative Pupillometry Values Are Similar in Bright Light and Dim Light Conditions.

Dimensions of critical care nursing : DCCN·2026

Same journal

Intravenous Smart Pump Alarms in Everyday Hospital Use: A Real-world Descriptive Analysis.

Dimensions of critical care nursing : DCCN·2026

Same journal

The Trajectories of Platelet, Fibrinogen, and D-dimer in Severe Trauma Patients and Their Value in Predicting Venous Thromboembolism: A Retrospective Study.

Dimensions of critical care nursing : DCCN·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 16, 2026

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

A Pilot Study Implementing a Protocol Using Dexmedetomidine as a Safe Alternative to Traditional Sedation to Decrease

Susan E Becker¹

¹Susan E. Becker, DNP, RN, CNS, CCRN, CCNS, is affiliated with the Duke University, Durham, North Carolina. She is an Assistant Professor of Nursing at the Malek School of Health Professionals of Marymount University, Virginia. She completed her DNP at Duke University in 2013 after finishing her BSN and MSN/CNS at George Mason University. Her research interests include intensive care and educational issues.

Dimensions of Critical Care Nursing : DCCN

|August 5, 2016

Summary

This summary is machine-generated.

Dexmedetomidine offers a safe alternative to traditional sedatives for mechanically ventilated patients, potentially reducing hospital stays without causing delirium or respiratory depression. This pilot study found it safe for difficult-to-extubate patients during weaning.

More Related Videos

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery

Published on: June 2, 2022

Related Experiment Videos

Last Updated: Mar 16, 2026

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery

Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery

Published on: June 2, 2022

Area of Science:

Critical Care Medicine
Pharmacology

Background:

Traditional sedatives for mechanically ventilated patients can cause delirium and respiratory depression, prolonging hospital stays.
Discontinuation of traditional sedatives for extubation can lead to patient anxiety and agitation, delaying the process.
Dexmedetomidine is a sedative that does not cause delirium or respiratory depression, allowing for continued use during weaning.

Purpose of the Study:

To decrease the length of stay for mechanically ventilated patients.
To implement a dexmedetomidine protocol for difficult-to-extubate patients during the weaning process.

Main Methods:

Pilot study utilizing a preintervention/postintervention design.
Comparison of the mean length of stay on mechanical ventilation.
Mann-Whitney U test employed due to small sample size.

Main Results:

Fifteen patients received dexmedetomidine during the 3-month implementation period.
No adverse reactions were reported in patients receiving dexmedetomidine.
A trend towards decreased mechanical ventilation length of stay was observed, though not statistically significant.

Conclusions:

Dexmedetomidine is a safe alternative to traditional sedation for difficult-to-extubate patients.
Safety was demonstrated when a bolus dose was not administered.