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The pattern visual evoked cortical response in human ageing.

J D Morrison1, J Reilly

  • 1Institute of Physiology, University of Glasgow.

Quarterly Journal of Experimental Physiology (Cambridge, England)
|May 1, 1989
PubMed
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Ageing affects visual processing speed, specifically slowing the pattern visual evoked response (PVER) at lower spatial frequencies. Increasing stimulus contrast can normalize PVER in older adults, suggesting age-related changes in the visual pathway.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Gerontology

Background:

  • The pattern visual evoked response (PVER) reflects visual pathway function.
  • Ageing is associated with changes in visual processing.
  • Specific components of PVER (N1, P1, N2, P2) are linked to different visual cortex areas.

Purpose of the Study:

  • To investigate the impact of ageing on PVER components.
  • To examine how spatial frequency and contrast affect PVER in young and old adults.
  • To explore potential mechanisms underlying age-related visual processing changes.

Main Methods:

  • Recorded PVER components (N1, P1, N2, P2) in young (15-34 yrs) and old (53-94 yrs) subjects.
  • Utilized sinusoidal grating patterns at 3 and 8 cycles/deg with varying contrasts (3-40%).

Related Experiment Videos

  • Analyzed time-to-peak, amplitude, and rise time of PVER components.

    • Main Results:

    • Time-to-peak for N1, P1, and N2 components increased with age, particularly at lower spatial frequencies (3 cycles/deg).
    • Amplitude and rise time showed no consistent age-related changes.
    • Increasing stimulus contrast normalized the time-to-peak differences between young and old groups at 3 cycles/deg.

    Conclusions:

    • Ageing selectively impacts low-spatial-frequency processing in the visual system.
    • These age-related changes appear to occur in the retino-geniculate pathway before the visual cortex.
    • PVER can be modulated by stimulus contrast, offering insights into age-related visual decline.