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Polycomb complex PRC1 as gatekeeper of intestinal stem cell identity

Nicolas Léveillé1, Louis Vermeulen1

  • 1Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, the Netherlands.

Stem Cell Investigation
|August 5, 2016
PubMed
Summary

Polycomb complex PRC1 maintains intestinal homeostasis by controlling Wnt signaling in adult stem cells. Inhibiting PRC1 blocks Wnt-driven tumors, offering new cancer stem cell therapy targets.

Keywords:
Polycomb complex PRC1Wnt pathwayintestinal stem cells (ISCs)

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