Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

765
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
765
Ventilatory Modes01:14

Ventilatory Modes

1.9K
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
1.9K
Hyperpnea and Hyperventilation01:25

Hyperpnea and Hyperventilation

3.6K
Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
3.6K
Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

Cardiopulmonary Resuscitation II: ACLS Airway Management

927
Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
927
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

4.5K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
4.5K
Mechanism of Breathing III: The Accessory Muscles01:21

Mechanism of Breathing III: The Accessory Muscles

5.1K
The Role of Accessory Muscles in the Respiratory System
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Methanesulfonamide Group: Bright and Dark Sides of hERG Potassium Channel Inhibition.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Comparison of Proteomic Analysis of Cerebrospinal Fluid From Neurological Patients With and Without Amyotrophic Lateral Sclerosis.

Journal of neurochemistry·2026
Same author

Myosin Post-Translational Modifications Associated With Critical Illness Myopathy.

Acta physiologica (Oxford, England)·2026
Same author

Systems neuroendocrinology in ME/CFS and long COVID: a chronobiological framework for hormone-based research.

Frontiers in neuroendocrinology·2026
Same author

Combatting ventilator induced diaphragm dysfunction with human bone marrow mesenchymal stromal cell-derived extracellular vesicles.

Skeletal muscle·2026
Same author

Designing studies for post-treatment Lyme disease and other infection-associated chronic illnesses.

Brain : a journal of neurology·2026

Related Experiment Video

Updated: Mar 16, 2026

Author Spotlight: Neuromotor Control and Recovery of Diaphragm Function Following Cervical Spinal Hemisection in Rats
05:09

Author Spotlight: Neuromotor Control and Recovery of Diaphragm Function Following Cervical Spinal Hemisection in Rats

Published on: June 14, 2024

941

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction.

Heba Salah1, Meishan Li2, Nicola Cacciani2

  • 1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm SE-177 77, Sweden. Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala 75124, Sweden.

Science Translational Medicine
|August 5, 2016
PubMed
Summary

Mechanical ventilation can cause diaphragm dysfunction (VIDD), but BGP-15 treatment improved muscle function in rats by preventing myosin damage. This suggests BGP-15 may help treat VIDD in intensive care unit patients.

More Related Videos

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes
05:51

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes

Published on: November 3, 2023

9.1K
Investigation into Deep Breathing through Measurement of Ventilatory Parameters and Observation of Breathing Patterns
08:34

Investigation into Deep Breathing through Measurement of Ventilatory Parameters and Observation of Breathing Patterns

Published on: September 16, 2019

12.2K

Related Experiment Videos

Last Updated: Mar 16, 2026

Author Spotlight: Neuromotor Control and Recovery of Diaphragm Function Following Cervical Spinal Hemisection in Rats
05:09

Author Spotlight: Neuromotor Control and Recovery of Diaphragm Function Following Cervical Spinal Hemisection in Rats

Published on: June 14, 2024

941
Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes
05:51

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes

Published on: November 3, 2023

9.1K
Investigation into Deep Breathing through Measurement of Ventilatory Parameters and Observation of Breathing Patterns
08:34

Investigation into Deep Breathing through Measurement of Ventilatory Parameters and Observation of Breathing Patterns

Published on: September 16, 2019

12.2K

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Molecular Biology

Background:

  • Ventilation-induced diaphragm dysfunction (VIDD) impairs diaphragm function during mechanical ventilation.
  • VIDD negatively impacts patient outcomes and healthcare systems, yet effective treatments are limited.
  • Understanding the molecular mechanisms of VIDD is crucial for developing interventions.

Purpose of the Study:

  • To investigate the effects of mechanical ventilation on diaphragm structure and function.
  • To evaluate the therapeutic potential of the pharmacological agent BGP-15 in mitigating VIDD.
  • To elucidate the molecular pathways, including myosin posttranslational modifications (PTMs), involved in VIDD.

Main Methods:

  • Utilized an experimental intensive care unit (ICU) rat model for time-resolved studies.
  • Administered the chaperone co-inducer BGP-15 to assess its impact on diaphragm function and structure.
  • Analyzed diaphragm muscle fiber function, atrophy, myosin PTMs, HSP72, PARP-1, and mitochondrial function.

Main Results:

  • Mechanical ventilation led to significant loss of diaphragm muscle fiber function due to myosin PTMs.
  • BGP-15 treatment (10 days) improved diaphragm muscle fiber function by approximately 100% without reversing atrophy.
  • BGP-15 protected against myosin PTMs, induced HSP72, inhibited PARP-1, and improved mitochondrial function and content.

Conclusions:

  • Mechanical ventilation-induced diaphragm dysfunction is associated with myosin posttranslational modifications.
  • The chaperone co-inducer BGP-15 demonstrates significant therapeutic potential for improving diaphragm muscle function in VIDD.
  • BGP-15 represents a promising intervention strategy for mechanically ventilated ICU patients suffering from VIDD.