Malignant plasma cells in cervical smear

This is a case report of a patient with diffuse multiple myeloma where atypical plasma cells were first discovered on routine blood and cervico-vaginal smears. Subsequent examination of a small endocervical mass and of the bone marrow revealed invasion by malignant plasma cells. Lytic bone lesions and extensive multiple organ system involvement developed despite chemotherapy and the patient expired five months after diagnosis. This case demonstrates that cervical smears, like other cytologic preparations, may contain malignant plasma cells and illustrates the importance of recognizing these cells.