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Angular default mode network connectivity across working memory load.

D Vatansever1,2, A E Manktelow1,2, B J Sahakian3

  • 1Division of Anaesthesia and Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.

Human Brain Mapping
|August 5, 2016
PubMed
Summary
This summary is machine-generated.

The default mode network (DMN) actively engages in working memory tasks. Its core regions, the angular gyri, show dynamic connectivity changes crucial for cognitive performance under increasing task demands.

Keywords:
angular gyrusbehavioral performancedefault mode networkfunctional connectivityintrinsic connectivity contrastn-backworking memory

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Brain Imaging

Background:

  • The default mode network (DMN) was initially identified during resting states.
  • Emerging evidence suggests DMN engagement in working memory tasks via flexible network interactions.
  • The DMN's role in whole-brain connectivity dynamics under varying working memory loads remains unclear.

Purpose of the Study:

  • To investigate the relationship between DMN hubs and working memory performance.
  • To assess DMN connectivity dynamics across increasing working memory loads using an fMRI n-back paradigm.
  • To identify specific DMN regions involved in adapting to task difficulty.

Main Methods:

  • Utilized functional magnetic resonance imaging (fMRI) during an n-back task with parametric load increases.
  • Employed a voxel-wise metric, the intrinsic connectivity contrast (ICC), to quantify global connectivity changes.
  • Conducted seed-based functional connectivity analyses focusing on identified DMN hubs.

Main Results:

  • Bilateral angular gyri, key DMN hubs, exhibited the most significant changes in global connectivity across n-back task loads.
  • Angular DMN regions demonstrated robust interactions with other large-scale brain networks.
  • Connectivity strength in the angular gyri positively correlated with reaction times for correct responses.

Conclusions:

  • The DMN is actively involved in the n-back working memory task.
  • Core DMN regions, specifically the angular gyri, play a critical role in modulating global brain connectivity.
  • These findings highlight the DMN's contribution to cognitive flexibility and information integration during demanding tasks.