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Issues and developments related to assessing function in serious mental illness.

Matt A Brown1, Dawn I Velligan1

  • 1Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA.

Dialogues in Clinical Neuroscience
|August 5, 2016
PubMed
Summary
This summary is machine-generated.

Developing new treatments for serious mental illness (SMI) requires better ways to measure functional outcomes. Current methods have limitations, necessitating reliable and valid alternatives for clinical trials.

Keywords:
assessmentfunctionfunctional capacitymeasurementoutcomeschizophreniaserious mental illness

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Area of Science:

  • Psychiatry and Mental Health
  • Clinical Psychology
  • Neuroscience

Background:

  • Serious mental illness (SMI) leads to significant functional disability, impacting individuals, caregivers, and society.
  • Novel treatments aim to improve cognitive and negative symptoms to enhance functional outcomes in SMI.
  • Current functional outcome assessments in SMI face challenges like instrument proliferation and varied stakeholder priorities.

Purpose of the Study:

  • To address limitations in current self- and informant-report functional assessments for serious mental illness (SMI).
  • To identify reliable, valid, and sensitive alternative strategies for assessing functioning in clinical trials for SMI.

Main Methods:

  • Review of challenges in assessing functional outcomes in serious mental illness (SMI).
  • Exploration of proposed measures of functional capacity for schizophrenia clinical trials.
  • Consideration of alternative approaches like effort-based decision making and daily activity recording.

Main Results:

  • Self- and informant-report measures have inherent limitations for assessing functional outcomes.
  • Measures of functional capacity are proposed for trials targeting cognitive impairment in schizophrenia.
  • Effort-based decision making and daily activity recording may suit studies on negative symptoms.

Conclusions:

  • There is a critical need for improved functional assessment strategies in serious mental illness (SMI) clinical trials.
  • Alternative methods beyond traditional self-report are necessary for accurate evaluation of treatment efficacy.
  • Specific approaches may be better suited for targeting cognitive versus negative symptoms in SMI research.