Effect of Ventolin on QTc in children with respiratory distress
Mohammad Reza Khalilian1, Abbas Fayezi2, Mohsen Alisamir2
1Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Nebulized Ventolin can alter QTc intervals in pediatric patients, but the 0.15 mg/kg/dose did not show significant changes compared to the 0.1 mg/kg/dose, suggesting a potentially safer dosing strategy for respiratory treatments.
Area of Science:
- Pediatric Cardiology
- Respiratory Medicine
- Pharmacology
Background:
- Beta-2 agonists are primary treatments for respiratory conditions.
- These medications may impact cardiac autonomic regulation.
- Assessing potential arrhythmogenic risks associated with Ventolin is crucial.
Purpose of the Study:
- To evaluate the effects of nebulized Ventolin on electrocardiogram (ECG) parameters.
- Specifically, to assess changes in the QTc interval and potential arrhythmogenic risks.
- To compare the effects of two different Ventolin dosages (0.1 mg/kg/dose vs. 0.15 mg/kg/dose).
Main Methods:
- A study involving 192 pediatric patients (2 months to 15 years) receiving nebulized Ventolin.
- Patients were divided into two groups based on dosage.
- ECGs were recorded before and after Ventolin administration, with data analyzed using a paired student's t-test.
Main Results:
- Statistically significant differences in QTc intervals were observed before and after Ventolin administration in both groups (P<0.005).
- No significant difference in Ventolin's effect on QTc interval was found between the two dosage groups.
- Heart rate showed significant changes post-Ventolin in the first group (P=0.009) but not in the second (P=0.345).
Conclusions:
- Nebulized Ventolin can induce changes in the QTc interval.
- The 0.15 mg/kg/dose of Ventolin did not result in significant QTc changes compared to the 0.1 mg/kg/dose.
- These findings suggest that higher doses of Ventolin may not pose a greater arrhythmogenic risk concerning QTc prolongation.
Introduction:
β2-agonists are first election drugs for the treatment of respiratory disease that may alter cardiac autonomic modulation. The aim of this study was to evaluate the effects of nebulized Ventolin on electrocardiogram, particularly QTc interval to assess the potential arrhythmogenic risks.
Methods:
A total of 192 patients between 2 months and 15 years which received nebulized Ventolin were enrolled in this study. Patients were divided into two groups. Electrocardiograms of patients before and after nebulized Ventolin were taken. Differences between two groups were assessed using a paired student's t test.
Results:
There was statistically significant differences in QTc before and after Ventolin in each groups (P<0.005).Ventolin effect on QTc interval in both groups did not differ. In first group, there was statistically significant differences between heart rate before and after Ventolin taken (P=0.009) but in second group there was not statistically significant differences between heart rate (P=0.345).
Conclusion:
Although Ventolin can cause changes in QTc, Ventolin with 0.15 mg/kg/dose in comparison with 0.1 mg/kg/dose does not cause significant changes in QTc.
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