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Updated: Mar 16, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Vitamin D and depression: A case series.

Pallavi S Nadkarni1, Gbolahan Odejayi2

  • 1Department of Psychiatry, Kingston General Hospital, Queen's University, Kingston, ON, Canada.

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|August 5, 2016
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Vitamin D deficiency is common in Canadians and can mimic depression symptoms. Supplementation improved symptoms in over 50% of deficient patients, avoiding unnecessary antidepressant use.

Keywords:
Treatment-resistant depressionsomatic symptomsvitamin D

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Area of Science:

  • Clinical Medicine
  • Nutritional Science
  • Psychiatry

Background:

  • Over two-thirds of Canadians exhibit vitamin D deficiency, a condition that can clinically overlap with depression.
  • Restricted routine vitamin D screening due to cost limitations complicates diagnosis and management.

Observation:

  • A case series screened 62 patients with treatment-resistant depression for vitamin D deficiency.
  • Patients with predominant somatic complaints underwent further screening for organic factors.

Findings:

  • Over 50% of evaluated patients were vitamin D deficient.
  • Vitamin D supplementation led to subjective symptom improvement without altering antidepressant prescriptions.

Implications:

  • Suspect vitamin D deficiency in depressed patients with somatic symptoms to reconsider treatment resistance.
  • Collaborative care with primary physicians is recommended for vitamin D management in psychiatric patients.