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Updated: Mar 16, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Liver dysfunction and anti-thyroid therapy
Danae A Papachristos1, Jenny Huynh1, Mathis Grossman2
1Department of Endocrinology and Diabetes, St Vincent's Hospital-Melbourne, Melbourne, VIC, Australia.
Abstract:
Thioamides have been used in the management of hyperthyroidism for over 50 years. Liver dysfunction is a rare but important side effect associated with their use. Recently, cases of liver failure associated with propylthiouracil have prompted the Federal Drug Administration to issue a Boxed Warning to the label of propylthiouracil regarding its risk of potentially fatal liver injury and acute liver failure in adults and children. Herein, we present a case to underline the importance of recognising the similar potential for severe hepatic dysfunction with the use of other thioamides.
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