Related Experiment Video
Updated: Mar 16, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Changing of IKZF1 genotype during Philadelphia-negative precursor-B acute lymphoblastic leukemia progression: a short
Volha Vshyukova1, Alexander Meleshko1, Natalia Mihal1
1Belarusian Research Centre for Pediatric Oncology, Hematology and Immunology, 223053, Republic of Belarus, Minsk region, v. Borovlyani, Frunzenskaya st., 43, Belarus.
Abstract:
•The case demonstrated a rare event of clonal heterogeneity by IKZF1 gene status in BCRABL1- ALL.•IKZF1 deletions are secondary events in ALL caused by clonal evolution during the treatment.•It's prognostic significance could be more crucial in BCR-ABL- rather than in BCR-ABL + ALL.•IKZF1 gene alterations may be determined and proved at the genome, expression and protein level.•IKZF1 deletions are suitable for MRD detection but not stable compared to Ig/TCR rearrangement.

