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A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination

Anders Lindholm Sørensen1, Klaus Kallenbach2, Hans Carl Hasselbalch3

  • 1Department of Hematology, Zealand University Hospital, Denmark; Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Copenhagen University Hospital, Denmark.

Leukemia Research Reports
|August 5, 2016
PubMed

We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.

Keywords:
AlendronateJAK2-V617F mutationMyeloproliferative neoplasmsPolycythemia veraSimvastatin

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