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Blood volume of children with leukemia

O Linderkamp, B Lau, K P Riegel

    Acta Paediatrica Scandinavica
    |May 1, 1978
    PubMed

    Insights

    Blood volume in children with acute lymphoblastic leukemia (ALL) is often normal but can increase with enlarged spleen and liver. This hypervolemia, driven by plasma expansion, may contribute to anemia through hemodilution.

    Area of Science:

    • Pediatric Hematology
    • Oncology
    • Clinical Physiology

    Background:

    • Acute lymphoblastic leukemia (ALL) is a common childhood cancer.
    • Understanding fluid balance and its impact on anemia in pediatric leukemia is crucial for effective management.

    Purpose of the Study:

    • To investigate blood volume and its components in children diagnosed with acute lymphoblastic leukemia.
    • To determine the relationship between hepatosplenomegaly and blood volume changes in pediatric leukemia patients.

    Main Methods:

    • Blood volume was quantified using 125iodinated human serum albumin.
    • Measurements were taken in children with ALL and other leukemia types.
    • Hematocrit and red cell mass were assessed in relation to spleen and liver size.

    Main Results:

    • Total blood volume was normal in patients without significant hepatosplenomegaly.
    • Blood volume increased progressively with spleen and liver enlargement, primarily due to plasma volume expansion.
    • Anemia in patients with hepatosplenomegaly may be partly attributed to hemodilution from expanded plasma volume.

    Conclusions:

    • Plasma volume expansion is a key factor in hypervolemia associated with hepatosplenomegaly in pediatric leukemia.
    • Hemodilution can contribute to anemia in children with leukemia, particularly those with enlarged spleen and liver.

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