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Socioeconomic Disadvantage Moderates the Association between Peripheral Biomarkers and Childhood Psychopathology

Rodrigo B Mansur1,2,3, Graccielle R Cunha1,2, Elson Asevedo1,2

  • 1National Institute of Developmental Psychiatry for Children and Adolescents, CNPq, São Paulo, Brazil.

Plos One
|August 5, 2016
PubMed

Insights

Socioeconomic disadvantage (SED) is linked to childhood mental health issues, potentially through biological pathways. Higher SED strengthens the connection between mental health problems and biomarkers like IL-6, TBARS, and BDNF.

Area of Science:

  • Child psychology
  • Neurobiology
  • Environmental health

Background:

  • Socioeconomic disadvantage (SED) is a known risk factor for early life mental health problems.
  • SED impacts biological systems, including neurotrophic factors, immune-inflammatory markers, and oxidative stress.
  • These biological markers are implicated in neurodevelopmental processes.

Purpose of the Study:

  • To investigate the relationship between socioeconomic disadvantage (SED), psychopathology domains, and serum levels of interleukin-6 (IL6), thiobarbituric acid-reactive substance (TBARS), and brain-derived neurotrophic factor (BDNF) in children.
  • To test if SED moderates the associations between mental health problems and these peripheral biomarkers.

Main Methods:

  • Cross-sectional study of 495 children aged 6-12.
  • Measured serum IL6, TBARS, and BDNF levels.
  • Assessed psychopathology using Child Behaviour Checklist (CBCL) DSM-oriented scales.
  • Evaluated SED using a cumulative risk model and analyzed data with generalized linear models.

Main Results:

  • SED was significantly associated with higher serum IL6 and TBARS levels, but not BDNF.
  • SED showed significant associations with all measured psychopathology domains (CBCL scales).
  • Serum biomarkers were linked to specific psychopathology subscales, and these associations were stronger in children with high SED, indicating a moderating effect.

Conclusions:

  • Socioeconomic disadvantage is strongly associated with mental health problems in children.
  • These associations may be mediated by interconnected neurobiological systems, highlighting the role of biomarkers.
Abstract

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