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Updated: Mar 16, 2026

Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery ALCAPA
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Transposition of the Great Arteries and Common Variants

Gil Wernovsky1

  • 1Department of Pediatrics, Section of Cardiology, Florida International University, Wertheim College of Medicine, Nicklaus Children's Hospital, Miami, FL.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|August 5, 2016
PubMed

Insights

The arterial switch operation significantly improved outcomes for infants with transposition of the great arteries. This review covers its physiology, management, and surgical success, highlighting advances in pediatric cardiovascular care.

Area of Science:

  • Pediatric Cardiovascular Surgery
  • Congenital Heart Disease Management

Background:

  • Transposition of the great arteries (TGA) is a critical congenital heart defect.
  • The arterial switch operation (ASO) has become a standard treatment for TGA.

Purpose of the Study:

  • To review the physiology of TGA.
  • To discuss perioperative management and surgical correction of TGA in infants undergoing ASO.
  • To analyze the outcomes of ASO for TGA.

Main Methods:

  • Literature review of MEDLINE and PubMed databases.
  • Synthesis of information on ASO for TGA.

Main Results:

  • Widespread adoption of ASO represents significant advances in pediatric cardiovascular care.
  • Improvements in diagnostics, surgical techniques, anesthesia, intensive care, and nursing have contributed to ASO success.
  • Strategies for TGA management have informed care for other neonatal congenital heart lesions.

Conclusions:

  • Continued research is needed on the long-term neurodevelopmental effects of perioperative care.
  • Collaboration among centers is essential to optimize outcomes, reduce costs, and minimize morbidity associated with ASO.
Abstract

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