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Comorbid Conditions in Neonates With Congenital Heart Disease

Ganga Krishnamurthy1, Veniamin Ratner, Emile Bacha

  • 11Department of Pediatrics, Section of Neonatology and Perinatology, Neonatal Cardiac Care, Columbia University College of Physicians and Surgeons, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY. 2Department of Pediatrics, Section of Neonatology and Perinatology, Columbia University College of Physicians and Surgeons, New York- Presbyterian Morgan Stanley Children's Hospital, New York, NY. 3Department of Surgery, Congenital and Pediatric Cardiac Surgery, Columbia University College of Physicians and Surgeons, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY. 4Department of Surgery, Columbia University College of Physicians and Surgeons, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|August 5, 2016
PubMed

Insights

Infants with congenital heart disease and noncardiac anomalies face higher mortality risks. Optimal outcomes require a collaborative, interdisciplinary approach for these complex cases.

Area of Science:

  • Pediatric Cardiology
  • Neonatology
  • Medical Genetics

Background:

  • Congenital heart disease (CHD) significantly increases mortality risk when associated with noncardiac anomalies.
  • Prematurity in infants with CHD presents unique challenges due to immature organ systems.
  • Management of these complex cases requires specialized, coordinated care.

Purpose of the Study:

  • To review the pathophysiology of major noncardiac anomalies in infants with CHD.
  • To discuss the clinical impact of these anomalies and prematurity on infants with CHD.
  • To outline current treatment strategies for these complex pediatric cases.

Main Methods:

  • Literature review of MEDLINE and PubMed databases.
  • Synthesis of information on pathophysiology, clinical impact, and treatment.
  • Focus on major noncardiac anomalies and prematurity in the context of CHD.

Main Results:

  • Noncardiac anomalies significantly elevate mortality in infants with CHD.
  • Several noncardiac anomalies necessitate neonatal surgery for survival.
  • Premature infants with CHD experience compounded physiological challenges.

Conclusions:

  • A collaborative, interdisciplinary approach is essential for optimal outcomes in premature infants and those with multiple congenital anomalies.
  • Effective management hinges on addressing both cardiac and noncardiac issues.
  • Early and coordinated interventions improve survival and quality of life.
Abstract

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