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Updated: Mar 16, 2026
Simultaneous Quantification of T-Cell Receptor Excision Circles TRECs and K-Deleting Recombination Excision Circles KRECs by Real-time PCR
Published on: December 6, 2014
[ERRORS IN DIAGNOSIS AND TREATMENT OF IMMUNODEPENDENT PATHOLOGY (ORIGINAL CONCEPT)].
This study highlights that many patients with undiagnosed illnesses suffer from decreased immunity due to infections like ascariasis and giardiasis. Addressing these underlying causes is crucial for effective treatment and immune restoration.
Area of Science:
- Infectious Diseases
- Immunology
- Clinical Diagnostics
Background:
- Many patients present with unverified primary diagnoses and compromised immune systems.
- Mixed infections involving bacterial, fungal, viral, protozoan, and helminthic agents are common.
- Identifying and addressing immunosuppression causes is key to managing complex infectious diseases.
Purpose of the Study:
- To investigate the prevalence of various infections and their role in immunosuppression among patients with unverified diagnoses.
- To evaluate the diagnostic value of immunological markers in identifying immune deficiencies.
- To propose a mixed approach for the treatment of infectious diseases based on comprehensive diagnostics.
Main Methods:
- Consultative-diagnostic assistance provided to 3965 patients over 2.5 years.
- Screening for common parasitic infections (ascariasis, giardiasis), candidiasis, and Epstein-Barr virus reactivation.
- Immunological assessments including neutrophil myeloperoxidase, lymphocyte subpopulations (natural killer cells), and immunoglobulin G (IgG) subclasses.
Main Results:
- High prevalence of ascariasis (55%) and giardiasis (65%) identified as potential causes of immunosuppression.
- Mucosal candidiasis (13%) and active Epstein-Barr virus (40%) were also frequently observed.
- Significant immune deficits noted, including reduced neutrophil myeloperoxidase (9.7%), natural killer cells (26.7%), and decreased IgG subclasses (22.1% for IgG1).
- Approximately 76% of patients exhibited a combination of decreased immunity.
Conclusions:
- A significant portion of patients with unverified diagnoses suffer from combined immune deficiencies, often linked to parasitic and opportunistic infections.
- Comprehensive immunological studies are essential for identifying the causes of immunosuppression.
- A multi-level diagnostic and treatment approach is necessary for effectively managing complex infectious diseases and restoring immune function.
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