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Updated: Mar 16, 2026

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

Published on: August 1, 2018

Ameloblastoma Phenotypes Reflected in Distinct Transcriptome Profiles.

Shijia Hu^1,2, Joel Parker³, Kimon Divaris^1,4

¹Pediatric Dentistry, School of Dentistry, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.

Scientific Reports

|August 6, 2016

Summary

This summary is machine-generated.

Ameloblastoma molecular subtypes were identified, revealing distinct pathways and gene alterations. This heterogeneity suggests tailored treatments may improve outcomes for this odontogenic neoplasm.

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Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

Area of Science:

Oral pathology
Molecular biology
Genomics

Background:

Ameloblastoma is a locally invasive benign neoplasm of odontogenic origin.
It exhibits diverse phenotypes but lacks molecular characterization.
High recurrence rates necessitate radical surgery, leading to significant morbidity.

Purpose of the Study:

To molecularly characterize ameloblastoma transcriptome.
To identify key genes and pathways involved in ameloblastoma development.
To compare ameloblastoma molecular profiles with normal odontogenic tissue.

Main Methods:

Laser capture microdissection of neoplastic epithelial tissue from 17 ameloblastomas.
Agilent 44k whole genome microarray analysis.
Transcriptome profiling and pathway analysis.

Main Results:

Ameloblastoma samples clustered into two distinct molecular groups associated with pre-secretory ameloblasts and odontoblasts.
Follicular type predominated in the pre-secretory cluster, while plexiform type was more common in the odontoblast cluster.
Commonly altered pathways included cell-cycle regulation, inflammation, and MAPK signaling, involving genes like TP53.

Conclusions:

Ameloblastoma exhibits significant inter-tumor molecular heterogeneity.
Distinct molecular subtypes correlate with histological patterns.
Findings support the development of tailored treatment strategies for ameloblastoma.