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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Mar 16, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
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Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

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The association between multiple sclerosis and uveitis.

Tine Gadegaard Olsen1, Jette Frederiksen1

  • 1Department of Neurology, Rigshospitalet-Glostrup, Glostrup, Denmark.

Survey of Ophthalmology
|August 6, 2016
PubMed
Summary
This summary is machine-generated.

The link between multiple sclerosis (MS) and uveitis is being investigated. Studies show uveitis affects about 1% of MS patients, and MS affects about 1% of uveitis patients, warranting further research.

Keywords:
autoimmune diseasemultiple sclerosisneurologyophthalmologysystematic reviewuveitis

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Area of Science:

  • Ophthalmology
  • Neurology
  • Immunology

Background:

  • The etiological association between multiple sclerosis (MS) and uveitis is debated.
  • Nerve and eye tissues share embryonic origins, suggesting a potential link.

Purpose of the Study:

  • To investigate the prevalence of uveitis in multiple sclerosis patients and vice versa.
  • To determine if the observed prevalence rates suggest a significant association.

Main Methods:

  • Review of published retrospective studies.
  • Analysis of prevalence data for MS in uveitis patients and uveitis in MS patients.

Main Results:

  • Reported prevalence of MS in uveitis patients varies widely (0.7%–30.4%).
  • Reported prevalence of uveitis in MS patients also varies widely (0.65%–36.7%).
  • Largest retrospective studies indicate approximately 1% prevalence for both conditions in the other's patient population.

Conclusions:

  • The prevalence of uveitis in MS patients and MS in uveitis patients is significantly higher than in the general population.
  • Further research is necessary to elucidate the relationship between MS and uveitis.