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Using the dendritic polymer PAMAM to form gold nanoparticles in the protein cage thermosome
Martin G Nussbaumer1, Christoph Bisig2, Nico Bruns2
1Department of Chemistry, University of Basel, Klingelbergstrasse 80, 4056 Basel, Switzerland and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts 02138, USA.
Abstract:
The chaperonin thermosome (THS) is a protein cage that lacks binding sites for metal ions and inorganic nanoparticles. However, when poly(amidoamine) (PAMAM) is encapsulated into THS, gold nanoparticles (AuNP) can be prepared in the THS. The polymer binds HAuCl4. Subsequent reduction yields nanoparticles with narrow size distribution in the protein-polymer conjugate.
