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Inducing and Evaluating Skeletal Muscle Injury by Notexin and Barium Chloride

Matthew T Tierney1,2, Alessandra Sacco3

  • 1Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.

Methods in Molecular Biology (Clifton, N.J.)
|August 6, 2016
PubMed

Keywords:
Muscle regenerationSkeletal muscle injury

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
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