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Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
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Characteristic calcaneal ossification: an additional early radiographic finding in infants with fibrodysplasia

Sachi Hasegawa1, Teresa Victoria2, Hülya Kayserili3

  • 1Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Pediatric Radiology
|August 6, 2016
PubMed

Insights

Abnormal calcaneal ossification, including double calcaneal centers and plantar spurs, is common in children with fibrodysplasia ossificans progressiva. These radiographic findings may aid in early diagnosis of this rare genetic disorder.

Area of Science:

  • Pediatric Radiology
  • Orthopedic Genetics
  • Skeletal Dysplasias

Background:

  • Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by progressive ectopic ossification.
  • Clinical observations noted abnormal calcaneal ossification in children diagnosed with FOP.

Purpose of the Study:

  • To investigate the significance of calcaneal ossification variants as radiographic markers in pediatric FOP.
  • To determine if specific calcaneal abnormalities are associated with FOP in children.

Main Methods:

  • Retrospective review of lateral foot radiographs from nine children diagnosed with FOP.
  • Radiographs were obtained during infancy and early childhood.

Main Results:

  • Eight out of nine children with FOP exhibited either double calcaneal ossification centers or plantar calcaneal spurs.
  • Double calcaneal ossification centers were observed in children aged 2-11 months.
  • Plantar calcaneal spurs were noted in 7 children, with a tendency to decrease in size with age.

Conclusions:

  • Double calcaneal ossification centers in infancy and plantar calcaneal spurs in childhood are frequent findings in FOP.
  • These calcaneal abnormalities may serve as valuable early radiographic indicators for diagnosing fibrodysplasia ossificans progressiva.
Abstract

Keywords:
Calcaneal spurChildrenDouble calcaneal ossification centerEarly diagnosisFibrodysplasia ossificans progressivaRadiography

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