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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Mar 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

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[Pyoderma gangrenosum].

K Herberger1

  • 1Comprehensive Wound Center (CWC), Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland. k.herberger@uke.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|August 6, 2016
PubMed
Summary

Pyoderma gangrenosum (PG) is a painful skin condition with unknown causes, diagnosed by exclusion. Treatment focuses on managing inflammation, associated diseases, and promoting wound healing.

Keywords:
ImmunosuppressionPainRecurrenceTreatmentWound healing

Related Experiment Videos

Last Updated: Mar 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
  • Its etiology remains largely unknown, complicating diagnosis and treatment.
  • PG often co-occurs with systemic diseases like inflammatory bowel disease and rheumatoid arthritis.

Purpose of the Study:

  • To review the diagnostic challenges and current therapeutic strategies for Pyoderma gangrenosum.
  • To highlight the importance of managing associated comorbidities and promoting wound healing.

Main Methods:

  • Literature review of diagnostic criteria and treatment outcomes for Pyoderma gangrenosum.
  • Analysis of current first-line and alternative treatment options, including systemic glucocorticosteroids, cyclosporine, and TNF-alpha antagonists.

Main Results:

  • Pyoderma gangrenosum is a diagnosis of exclusion, characterized by painful ulcerations with specific clinical features.
  • Over 50% of patients have associated systemic diseases, necessitating comprehensive management.
  • Systemic glucocorticosteroids and cyclosporine are recommended first-line treatments, with evidence suggesting efficacy of TNF-alpha antagonists.

Conclusions:

  • Effective Pyoderma gangrenosum management requires addressing inflammation, comorbidities, wound healing, and pain.
  • The chronic and recurrent nature of PG underscores the need for well-tolerated, long-term treatment strategies.